3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester

Base Information

• Chemical Name: 3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester
• CAS No.: 341925-76-6
• Molecular Formula: C₃₀H₅₀N₂O₅
• Molecular Weight: 518.737
• Mol file: 341925-76-6.mol

Synonyms:3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester

Chemical Property of 3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester

There total 3 articles about 3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-hexadecylcarboxylic acid (57-10-3) + 3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester (341925-61-9) → 3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester (341925-76-6)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In chloroform; at 0 - 20 ℃; for 21h;

DOI:10.1021/jo001079t

Reference yield:

3.5-diaminobenzoic acid (535-87-5) → 3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester (341925-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / SOCl₂ / 24 h / Heating

2: 83 percent / Et₃N / H₂O; dioxane / 11 h / 0 - 20 °C

3: 93 percent / Et₃N; dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / CHCl₃ / 21 h / 0 - 20 °C

With thionyl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; chloroform; water;

DOI:10.1021/jo001079t

Reference yield:

3,5-diaminobenzoic acid ethyl ester (1949-51-5) → 3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester (341925-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Et₃N / H₂O; dioxane / 11 h / 0 - 20 °C

2: 93 percent / Et₃N; dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / CHCl₃ / 21 h / 0 - 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; chloroform; water;

DOI:10.1021/jo001079t

upstream raw materials:

1-hexadecylcarboxylic acid

3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester

3.5-diaminobenzoic acid

3,5-diaminobenzoic acid ethyl ester

Downstream raw materials:

3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester

3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-hexadecanoylamino)benzoic acid

3-amino-5-(N-hexadecanoylamino)benzoic acid ethyl ester