α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester

Base Information

• Chemical Name: α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester
• CAS No.: 137586-95-9
• Molecular Formula: C₂₄H₂₅FO₄
• Molecular Weight: 396.459

Synonyms:α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester

Chemical Property of α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester

There total 3 articles about α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzaldehyde (459-57-4) → α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester (137586-95-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

With piperidine; acetic acid; lithium hexamethyldisilazane; In benzene;

DOI:10.1021/jm00113a019

Reference yield:

Ethyl 3-cyclopropyl-3-oxopropionate (24922-02-9) → α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester (137586-95-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

With piperidine; acetic acid; lithium hexamethyldisilazane; In benzene;

DOI:10.1021/jm00113a019

Reference yield:

→ α-(1-Cyclopropyl-1-oxomethyl)-β-(4-fluorophenyl)-γ-methyl-Δ-oxophenylpentanoic acid, ethyl ester (137586-95-9)

Guidance literature:

upstream raw materials:

4-fluorobenzaldehyde

Ethyl 3-cyclopropyl-3-oxopropionate

Downstream raw materials:

(S)-4-[[[2-Cyclopropyl-4-(4-fluorophenyl)-5-methyl-6-phenyl-3-pyridinyl]ethynyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-5-methyl-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate

(S,E)-4-[[2-[2-Cyclopropyl-4-(4-fluorophenyl)-5-methyl-6-phenyl-3-pyridinyl]ethenyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

(S)-4-[[[2-Cyclopropyl-4-(4-fluorophenyl)-5-methyl-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

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