4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester

Base Information

• Chemical Name: 4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester
• CAS No.: 188909-15-1
• Molecular Formula: C₅₃H₇₈N₄O₁₃
• Molecular Weight: 979.221

Synonyms:4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester

Chemical Property of 4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester

Chemical Property:

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Technology Process of 4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester

There total 8 articles about 4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-benzyloxycarbonyl-2-phenyl-ethyl ester (188909-13-9) → 4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester (188909-15-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2327.17 - 2585.74 Torr;

DOI:10.1021/jm020482k

Reference yield:

(R)-2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-4-methylpentanoyloxy)propanoic acid (157567-62-9) → 4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester (188909-15-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

2: 100 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

3: 58 percent Spectr_. / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

4: 99 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

5: 93 percent Spectr_. / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm020482k

Reference yield:

benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate (157567-64-1) → 4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester (188909-15-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

2: 58 percent Spectr_. / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

3: 99 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

4: 93 percent Spectr_. / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm020482k

upstream raw materials:

4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-benzyloxycarbonyl-2-phenyl-ethyl ester

(R)-2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-4-methylpentanoyloxy)propanoic acid

N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid

benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate

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