benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate

Base Information

Chemical Name:benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate
CAS No.:157567-64-1
Molecular Formula:C₃₈H₅₄N₂O₉
Molecular Weight:682.855
Hs Code.:

Synonyms:benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate

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Chemical Property of benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate

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Technology Process of benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate

There total 5 articles about benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 157567-62-9
(R)-2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-4-methylpentanoyloxy)propanoic acid

: 157567-63-0
benzyl N-methyl-L-leucyl-3-phenyl-D-lactate

: 157567-64-1
benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;

Reference yield:

: 153052-68-7
(2R)-1-(benzyloxy)-1-oxopropan-2-yl (2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-4-methylpentanoate

: 157567-64-1
benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

2: 80 percent / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm020482k

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 157567-64-1
benzyl N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / NaH / tetrahydrofuran

2: 94 percent / PPh₃, diethyl azodicarboxylate / diethyl ether

3: H₂ / Pd-C / methanol

4: 91 percent / DCC, HOBt, 4-methylmorpholine / tetrahydrofuran

With 4-methyl-morpholine; hydrogen; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;