2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide

Base Information

Chemical Name:2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide
CAS No.:431980-38-0
Molecular Formula:C₂₀H₁₆N₂O₄S
Molecular Weight:380.424
Hs Code.:
DSSTox Substance ID:DTXSID70361711
Nikkaji Number:J2.647.399C
Wikidata:Q82144173
ChEMBL ID:CHEMBL1213418
Mol file:431980-38-0.mol

Synonyms:RN-18;431980-38-0;2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide;N-(2-methoxyphenyl)-2-(4-nitrophenyl)sulfanylbenzamide;CHEMBL1213418;N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)benzamide;N-(2-methoxyphenyl)-2-[(4-nitrophenyl)thio]-benzamide;N-(2-Methoxyphenyl)-2-[(4-nitrophenyl)thio]benzamide;Cambridge id 6776439;Oprea1_288287;SCHEMBL2954791;N-(2-methoxyphenyl)-2-(4-nitrophenyl)sulfanyl-benzamide;DTXSID70361711;BCP33989;EX-A5626;RN 18;RN18;BDBM50534561;AKOS040742558;CS-6953;BS-17070;HY-102014;C75161;AB00118891-01;A913675;BRD-K43096780-001-01-6;Benzamide, N-(2-methoxyphenyl)-2-[(4-nitrophenyl)thio]-;[4-[2-[(2-methoxyphenyl)carbamoyl]phenyl]sulfanylphenyl]azinic acid

Suppliers and Price of 2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
RN-18 >98%
250 mg
$ 900.00

DC Chemicals
RN-18 >98%
1 g
$ 1700.00

ChemScene
RN-18 99.37%
100mg
$ 1128.00

ChemScene
RN-18 99.37%
10mg
$ 180.00

ChemScene
RN-18 99.37%
5mg
$ 108.00

ChemScene
RN-18 99.37%
25mg
$ 384.00

ChemScene
RN-18 99.37%
50mg
$ 648.00

Cayman Chemical
RN-18 ≥98%
25mg
$ 550.00

Cayman Chemical
RN-18 ≥98%
10mg
$ 251.00

Cayman Chemical
RN-18 ≥98%
1mg
$ 32.00

Total 6 raw suppliers

Chemical Property of 2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide

Chemical Property:

Boiling Point:493.6±40.0 °C(Predicted)
PKA:12.33±0.70(Predicted)
Density:1.36±0.1 g/cm3(Predicted)
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:380.08307817
Heavy Atom Count:27
Complexity:505

Purity/Quality:

97% ^*data from raw suppliers

RN-18 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1NC(=O)C2=CC=CC=C2SC3=CC=C(C=C3)[N+](=O)[O-]
Uses RN-18 is a selective inhibitor of?virion infectivity factor (Vif)?APOBEC interactions and HIV-1 replication.

Technology Process of 2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide

There total 7 articles about 2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 20904-30-7
2-((4-nitrophenyl)thio)benzoic acid

: 90-04-0
2-methoxy-phenylamine

: 431980-38-0
N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)benzamide

Guidance literature:: 2-((4-nitrophenyl)thio)benzoic acid; With thionyl chloride; In N,N-dimethyl-formamide; benzene; at 80 ℃; for 2h;

2-methoxy-phenylamine; With triethylamine; In N,N-dimethyl-formamide; benzene; at 80 ℃; for 5h;
DOI:10.1021/ml300037k

Reference yield: 63.0%

: 36684-47-6
2-iodo-N-(2-methoxy-phenyl)-benzamide

: 1849-36-1
para-nitrobenzenethiol

: 431980-38-0
N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)benzamide

Guidance literature:: With potassium carbonate; ethylene glycol; copper(l) iodide; In isopropyl alcohol; at 20 ℃; for 1h; Product distribution / selectivity; microwave irradiation;

Reference yield:

: 96198-56-0
2-((4-nitrophenyl)thio)benzoyl chloride

: 431980-38-0
N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / N,N-dimethyl-formamide; benzene / Reflux

2.1: thionyl chloride / N,N-dimethyl-formamide; benzene / 2 h / 80 °C

2.2: 5 h / 80 °C

With thionyl chloride; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/ml300037k