tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate

Base Information

• Chemical Name: tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate
• CAS No.: 1148155-01-4
• Molecular Formula: C₃₃H₅₅N₅O₇
• Molecular Weight: 633.829
• Mol file: 1148155-01-4.mol

Synonyms:tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate

Chemical Property of tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate

There total 3 articles about tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

tert-butyl [4,7-bis-tert-butoxycarbonylmethyl-10-(4-nitrobenzoyl)-1,4,7,10-tetraazacyclododec-1-yl]acetate (1148155-00-3) → tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate (1148155-01-4)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; for 2h;

DOI:10.1055/s-0028-1083335

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate (1148155-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: iron; ammonium chloride; acetic acid / ethanol; water / 8 h / 50 °C / Sonication

With iron; ammonium chloride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1002/bio.3883

Reference yield:

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) → tert-butyl [4-(4-aminobenzoyl)-7,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl]acetate (1148155-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: iron; ammonium chloride; acetic acid / ethanol; water / 8 h / 50 °C / Sonication

With iron; ammonium chloride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1002/bio.3883

upstream raw materials:

tert-butyl [4,7-bis-tert-butoxycarbonylmethyl-10-(4-nitrobenzoyl)-1,4,7,10-tetraazacyclododec-1-yl]acetate

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

4-nitro-benzoyl chloride