5H-Cyclopenta(d)pyrazolo(1,5-a)pyrimidin-8-amine, 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6,7-dihydro-2-methyl-

Base Information

Chemical Name:5H-Cyclopenta(d)pyrazolo(1,5-a)pyrimidin-8-amine, 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6,7-dihydro-2-methyl-
CAS No.:441060-02-2
Molecular Formula:C₂₂H₂₇ClN₄O
Molecular Weight:398.936
Hs Code.:
UNII:T989JBG788
Wikidata:Q27289839
Pharos Ligand ID:KL1CJGKALSQV
ChEMBL ID:CHEMBL1819077

Synonyms:ONO-2333;ONO-2333Ms;T989JBG788;UNII-T989JBG788;CHEMBL1819077;441060-02-2;(1-Ethyl-propyl)-(3-(4-methoxy-2-chlorophenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-S-indacen-8-yl)-amine;10-(2-Chloro-4-methoxyphenyl)-11- methyl-N-(pentan-3-yl)-1,8,12-triazatricyclo(7.3.0.03,7)dodeca-2,7,9,11-tetraen-2-amine;5H-Cyclopenta(d)pyrazolo(1,5-a)pyrimidin-8-amine, 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6,7-dihydro-2-methyl-;ONO2333MS;SCHEMBL1868423;GTPL10376;ONO2333;LDIOUQIXNSSOGU-UHFFFAOYSA-N;BDBM50351387;compound 7b [PMID: 21865047];Q27289839;8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine

Suppliers and Price of 5H-Cyclopenta(d)pyrazolo(1,5-a)pyrimidin-8-amine, 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6,7-dihydro-2-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5H-Cyclopenta(d)pyrazolo(1,5-a)pyrimidin-8-amine, 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6,7-dihydro-2-methyl-

Chemical Property:

XLogP3:5.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:398.1873392
Heavy Atom Count:28
Complexity:519

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(CC)NC1=C2CCCC2=NC3=C(C(=NN31)C)C4=C(C=C(C=C4)OC)Cl
Recent ClinicalTrials:Placebo-Controlled Study of ONO-2333Ms in Patients With Recurrent Major Depressive Disorder

Technology Process of 5H-Cyclopenta(d)pyrazolo(1,5-a)pyrimidin-8-amine, 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6,7-dihydro-2-methyl-

There total 6 articles about 5H-Cyclopenta(d)pyrazolo(1,5-a)pyrimidin-8-amine, 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6,7-dihydro-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 817636-91-2
8-chloro-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine

: 616-24-0
3-aminopentane

: 441060-02-2
(1-ethyl-propyl)-[3-(4-methoxy-2-chlorophenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl]-amine

Guidance literature:: In isopropyl alcohol; at 20 - 90 ℃; for 4h;
DOI:10.1016/j.bmc.2011.07.055

Reference yield:

: 50638-46-5
4-bromo-3-chloroanisole

: 441060-02-2
(1-ethyl-propyl)-[3-(4-methoxy-2-chlorophenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium diacetate; triphenylphosphine / diethylene glycol dimethyl ether / 0.5 h / 110 °C

1.2: 7 h / 110 - 115 °C

2.1: acetic acid; hydrazine / water; toluene / 7 h / 45 - 55 °C

2.3: pH 6.5 - 7.5

3.1: acetic acid / ethanol / 7 h / Heating / reflux

3.2: 0.5 h / 40 - 65 °C

4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 9 h / 80 - 95 °C

5.1: triethylamine / N,N-dimethyl acetamide; isopropyl alcohol / 4 h / 95 - 105 °C

With acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; trichlorophosphate; palladium diacetate; triphenylphosphine; In ethanol; diethylene glycol dimethyl ether; N,N-dimethyl acetamide; water; isopropyl alcohol; toluene;

Reference yield:

: 817636-90-1
8-hydroxy-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine

: 441060-02-2
(1-ethyl-propyl)-[3-(4-methoxy-2-chlorophenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diethylaniline; trichlorophosphate / toluene / 5 h / 20 °C / Reflux

2: isopropyl alcohol / 4 h / 20 - 90 °C

With N,N-diethylaniline; trichlorophosphate; In isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2011.07.055