50638-46-5

Basic information

• Product Name: 4-Bromo-3-chloroanisole
• Synonyms: 3-CHLORO-4-BROMOANISOLE;4-BROMO-3-CHLOROANISOLE;1-BROMO-2-CHLORO-4-METHOXYBENZENE;4-Bromo-3-chloroanisole 99%;4-Bromo-3-chloroanis
• CAS NO: 50638-46-5
• Molecular Formula: C₇H₆BrClO
• Molecular Weight: 221.48
• Product Categories: blocks;Bromides;Aromatic Ethers;Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Chlorine Compounds;Benzenes
• Mol File: 50638-46-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 129-132°C
• Flash Point: 106.8 °C
• Appearance: /
• Density: 1.564 g/cm³
• Vapor Pressure: 0.03mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Bromo-3-chloroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-chloroanisole(50638-46-5)
• EPA Substance Registry System: 4-Bromo-3-chloroanisole(50638-46-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-51
• Hazardous Substances Data: 50638-46-5(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

InChI:InChI=1/C7H6BrClO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,1H3

Upstream product

• 13631-21-5 4-bromo-3-chlorophenol 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 21402-26-6 4-bromo-3-chloroaniline 
• 74-88-4 methyl iodide 
• 21971-21-1 2-chloro-4-methoxybenzoic acid 
• 3260-88-6 1-chloro-3-methoxy-2-methylbenzene 
• 29682-39-1 1-bromo-2-chloro-4-nitrobenzene 
• 29866-54-4 2-chloro-6-methoxybenzaldehyde 

Downstream Products

• 775345-62-5 4-hydroxy-1-(2-chloro-4-methoxyphenyl)-2-methylbutan-1-one 
• 441060-95-3 2-(2-chloro-4-methoxyphenyl)-3-oxo-butyronitrile 
• 941696-25-9 4-(2-chloro-4-methoxyphenyl)-2-methyl-3-butyn-2-ol 
• 89691-59-8 1-(2-chloro-4-methoxy-phenyl)-ethanol 
• 219735-99-6 2-chloro-4-methoxyphenylboronic acid 
• 944819-09-4 3-(2-chloro-4-methoxy-phenyl)-propenal 
• 1331753-56-0 tert-butyl 2-((2-chloro-4-methoxyphenyl)amino)benzoate 
• 1293343-40-4 1-(2-bromophenylsulfanyl)-2-chloro-4-methoxybenzene 
• 1293343-75-5 4-[2-(2-chloro-4-methoxyphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1293343-07-3 1-[2-(2-chloro-4-methoxyphenylsulfanyl)phenyl]piperazine hydrochloride 
• 2845-89-8 1-chloro-3-methoxy-benzene 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

The present invention provides a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.

Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

Methods for the conversion of aliphatic acids to alkyl halides have progressed significantly over the past century, however, the analogous decarboxylative bromination of aromatic acids has remained a longstanding challenge. The development of efficient methods for the synthesis of aryl bromides is of great importance as they are versatile reagents in synthesis and are present in many functional molecules. Herein we report a transition metal-free decarboxylative bromination of aromatic acids. The reaction is applicable to many electron-rich aromatic and heteroaromatic acids which have previously proved poor substrates for Hunsdiecker-type reactions. In addition, our preliminary mechanistic study suggests that radical intermediates are not involved in this reaction, which is in contrast to classical Hunsdiecker-type reactivity. Overall, the process demonstrates a useful method for producing valuable reagents from inexpensive and abundant starting materials.

Poly(4-vinylpyridinium bromochromate): An efficient reagent for bromination of aromatic compounds

A simple and efficient method for the bromination of various aromatic compounds by using poly(4-vinylpyridinium bromochromate) is reported. This method has several advantages such as good selectivity between ortho and para positions of aromatic compounds, simple workup, short reaction times, and high yields of the products.