N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide

Base Information

Chemical Name:N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide
CAS No.:1624605-35-1
Molecular Formula:C₁₈H₁₄Cl₂F₄N₄O₂
Molecular Weight:465.234
Hs Code.:

Synonyms:N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide

Suppliers and Price of N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide

There total 7 articles about N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86873-60-1
5-chloropicolinic acid

: 1624606-94-5
(4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1624605-35-1
N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide

Guidance literature:: With sodium hydrogencarbonate; trifluoroacetic acid; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: (R)-N-((S)-2-(2-chloro-3-fluorophenyl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

: 1624605-35-1
N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide

Guidance literature:: Multi-step reaction with 7 steps

1: dichloromethane

2: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran

3: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; methanol; 1,4-dioxane

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol

5: sodium carbonate / sulfuric acid

6: acetic acid

7: trifluoroacetic acid; sodium hydrogencarbonate / ethyl acetate; water; N,N-dimethyl-formamide

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; sulfuric acid; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: (R)-N-((2S,4S)-2-(2-chloro-3-fluorophenyl)-5,5,5-trifluoro-4-hydroxypentan-2-yl)-2-methylpropane-2-sulfinamide

: 1624605-35-1
N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; methanol; 1,4-dioxane

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol

3: sodium carbonate / sulfuric acid

4: acetic acid

5: trifluoroacetic acid; sodium hydrogencarbonate / ethyl acetate; water; N,N-dimethyl-formamide

With hydrogenchloride; sodium hydrogencarbonate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; sulfuric acid; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;