(4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Base Information

Chemical Name:(4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
CAS No.:1624606-94-5
Molecular Formula:C₁₂H₁₂ClF₄N₃O
Molecular Weight:325.693
Hs Code.:

Synonyms:(4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

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Chemical Property of (4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Chemical Property:

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Technology Process of (4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

There total 6 articles about (4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.9%

: 1624606-93-4
(4S,6S)-4-(2-chloro-3-fluoro-5-nitrophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 76-05-1
trifluoroacetic acid

: 1624606-94-5
(4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: In acetic acid;

Reference yield:

: (R)-N-((S)-2-(2-chloro-3-fluorophenyl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

: 1624606-94-5
(4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane

2: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran

3: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; methanol; 1,4-dioxane

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol

5: sodium carbonate / sulfuric acid

6: acetic acid

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; sulfuric acid; acetic acid; ethyl acetate;

Reference yield:

: (R)-N-((2S,4S)-2-(2-chloro-3-fluorophenyl)-5,5,5-trifluoro-4-hydroxypentan-2-yl)-2-methylpropane-2-sulfinamide

: 1624606-94-5
(4S,6S)-4-(5-amino-2-chloro-3-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; methanol; 1,4-dioxane

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol

3: sodium carbonate / sulfuric acid

4: acetic acid

With hydrogenchloride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; sulfuric acid; acetic acid; ethyl acetate;