2-chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

Base Information

• Chemical Name: 2-chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride
• CAS No.: 1105129-06-3
• Molecular Formula: C₁₄H₂₂ClFN₄*ClH
• Molecular Weight: 337.268

Synonyms:2-chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

Chemical Property of 2-chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

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Technology Process of 2-chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

There total 1 articles about 2-chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-amino-1,2,2,6,6-pentamethylpiperidine (40327-96-6) + 2,4-dichloro-5-fluoropyrimidine (2927-71-1) → 2-chloro-5-fluoro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride (1105129-06-3)

Guidance literature:

In methanol; at 20 ℃;

Reference yield: 93.0%

2-chloro-5-fluoro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride (1105129-06-3) + C11H13N5O2 (1239596-42-9) → 5-fluoro-N2-(3-(1-methyl-1H-tetrazol-5-yl)-5-(oxetan-3-yloxy)phenyl)-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine (1239596-28-1)

Guidance literature:

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In 1,4-dioxane; at 160 ℃; for 1h; Microwave irradiation;

Reference yield: 84.0%

4-(4-methyl-1-piperazinyl)-3-(trifluoromethyl)aniline (330796-48-0) + 2-chloro-5-fluoro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride (1105129-06-3) → 5-fluoro-N2-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-2,4-pyrimidinediamine

Guidance literature:

With trifluoroacetic acid; In isopropyl alcohol; at 100 ℃;

upstream raw materials:

4-amino-1,2,2,6,6-pentamethylpiperidine

2,4-dichloro-5-fluoropyrimidine

Downstream raw materials:

5-fluoro-N₂-(3-(1-methyl-1H-tetrazol-5-yl)-5-(oxetan-3-yloxy)phenyl)-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine

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