methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

Base Information

Chemical Name:methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate
CAS No.:1391826-46-2
Molecular Formula:C₂₃H₃₅FN₂O₅
Molecular Weight:438.54
Hs Code.:

Synonyms:methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

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Chemical Property of methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

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Technology Process of methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

There total 5 articles about methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86834-94-8
Boc-(S)-β³-HLeu-OMe

: 1391826-46-2
methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201200313

Reference yield:

: 52716-48-0
(3S)-3-<(tert-butoxy)carbonylamino>-1-diazo-5-methylhexan-2-one

: 1391826-46-2
methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: silver benzoate; silica gel / 0.25 h / 50 °C

2: dichloromethane / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With silver benzoate; silica gel; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201200313

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 1391826-46-2
methyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.25 h / -30 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: silver benzoate; silica gel / 0.25 h / 50 °C

3.1: dichloromethane / 18 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With silver benzoate; chloroformic acid ethyl ester; silica gel; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201200313