4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

Base Information

Chemical Name:4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate
CAS No.:1391826-36-0
Molecular Formula:C₂₈H₃₆BrFN₂O₅
Molecular Weight:579.507
Hs Code.:

Synonyms:4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

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Chemical Property of 4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

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Technology Process of 4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

There total 8 articles about 4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 106-41-2
4-bromo-phenol

: 1391826-47-3
C₂₂H₃₃FN₂O₅

: 1391826-36-0
4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/chem.201200313

Reference yield:

: 52716-48-0
(3S)-3-<(tert-butoxy)carbonylamino>-1-diazo-5-methylhexan-2-one

: 1391826-36-0
4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: silver benzoate; silica gel / 0.25 h / 50 °C

2: dichloromethane / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

4: water; lithium hydroxide / methanol / 18 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

With dmap; water; silver benzoate; silica gel; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201200313

Reference yield:

: 86834-94-8
Boc-(S)-β³-HLeu-OMe

: 1391826-36-0
4-bromophenyl (S)-3-((R)-2-benzyl-3-(tert-butoxycarbonylamino)-2-fluoropropanamido)-5-methylhexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

3: water; lithium hydroxide / methanol / 18 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201200313