Technology Process of 7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(4-bromo-2-chlorophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one
There total 10 articles about 7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(4-bromo-2-chlorophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium carbonate / acetone / 24 h / 50 °C
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
2.2: 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
4.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 5 h / 20 °C
5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere
7.1: toluene-4-sulfonic acid / 1 h
8.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 20 °C
9.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 3 h / Reflux
10.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C
With
dmap; N-Bromosuccinimide; n-butyllithium; sodium azide; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; diisopropylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
1.2: 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
3.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 5 h / 20 °C
4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere
6.1: toluene-4-sulfonic acid / 1 h
7.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 20 °C
8.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 3 h / Reflux
9.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C
With
dmap; N-Bromosuccinimide; n-butyllithium; sodium azide; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; diisopropylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
