(3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one

Base Information

Chemical Name:(3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one
CAS No.:581060-44-8
Molecular Formula:C₃₂H₄₆O₉SSi
Molecular Weight:634.863
Hs Code.:

(3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one

Synonyms:(3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one

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Chemical Property of (3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one

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Technology Process of (3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one

There total 18 articles about (3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 905312-47-2
Toluene-4-sulfonic acid (1R,3S,4R,4aR,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-5-methoxymethoxy-3-methyl-octahydro-isochromen-4-yl ester

: 581060-44-8
(3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one

Guidance literature:: With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.tet.2006.04.079

Reference yield: 72.0%

: 581060-42-6
(1R,2R,3S,4S,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-3-methoxymethoxy-2-[(R)-2-oxo-1-(toluene-4-sulfonyloxy)-propyl]-cyclohexanecarboxylic acid

: 581060-44-8
(3S,4R,4aS,5S,6S,8R,8aR)-6-benzyloxy-8-(tert-butyldimethylsilyloxy)-5-methoxymethyloxy-3-methyl-4-(p-toluenesulfonyloxy)-perhydroisochroman-1-one

Guidance literature:: (1R,2R,3S,4S,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-3-methoxymethoxy-2-[(R)-2-oxo-1-(toluene-4-sulfonyloxy)-propyl]-cyclohexanecarboxylic acid; With sodium tetrahydroborate; In methanol;

With dmap; dicyclohexyl-carbodiimide;
DOI:10.1016/S0040-4039(03)01186-9