Technology Process of C14H18O4
There total 6 articles about C14H18O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
malonic acid dimethyl ester;
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2.5h;
Inert atmosphere;
Schlenk technique;
S-(-)-1-bromo-2-phenylpropane;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/jacs.9b09301
- Guidance literature:
-
malonic acid dimethyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.25h;
(S)-(2-iodo-1-methylethyl)benzene;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 13h;
DOI:10.1002/adsc.201300250
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: (5S)-(?)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride / water; acetonitrile / 24 h / 0 °C
2.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
3.1: hydrogen / water; ethanol / 3 h / 760.05 Torr
4.1: iodine; 1H-imidazole; triphenylphosphine / acetonitrile; diethyl ether / 4.5 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C
5.2: 13 h / 20 °C
With
1H-imidazole; sodium tetrahydroborate; hydrogen; iodine; sodium hydride; triphenylphosphine; (5S)-(?)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride;
In
methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1002/adsc.201300250
