methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate

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Chemical Name:methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate
CAS No.:119706-43-3
Molecular Formula:C₂₉H₃₁N₃O₇
Molecular Weight:533.581
Hs Code.:

Synonyms:methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate

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Chemical Property of methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate

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Technology Process of methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate

There total 3 articles about methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 119706-40-0
methyl 5(S)-N-(benzyloxycarbonyl)amino-6-(indol-3-yl)-2-methoxycarbonyl-4-oxohexanoate

: 5332-06-9
4-bromobutanenitrile

: 119706-43-3
methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate

Guidance literature:: With sodium hydride; sodium iodide; In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86018-X

Reference yield:

: 61846-16-0
Z-Trp-CH₂Cl

: 119706-43-3
methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / sodium iodide / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

2: 67 percent / NaH, sodium iodide / tetrahydrofuran / 24 h / Ambient temperature

With sodium hydride; sodium iodide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4020(01)86018-X

Reference yield:

: 7432-21-5
N-carbobenzyloxy-L-tryptophane

: 119706-43-3
methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate

Guidance literature:: Multi-step reaction with 3 steps

2: 92 percent / sodium iodide / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

3: 67 percent / NaH, sodium iodide / tetrahydrofuran / 24 h / Ambient temperature

With sodium hydride; sodium iodide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4020(01)86018-X