ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Base Information

• Chemical Name: ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate
• CAS No.: 1356601-56-3
• Molecular Formula: C₂₉H₃₀N₂O₆
• Molecular Weight: 502.567
• Mol file: 1356601-56-3.mol

Synonyms:ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Chemical Property of ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

There total 6 articles about ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ethyl 3-{2-hydroxy-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (1356601-53-0) + chloroacetonitrile (107-14-2) → ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (1356601-56-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 0 - 80 ℃; for 16h;

Reference yield:

2,4-Dihydroxybenzaldehyde (95-01-2) → ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (1356601-56-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 0.25 h / 20 °C

1.2: 3 h / 20 - 80 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 16 h / 0 - 20 °C

3.1: hydrogen / palladium(II) hydroxide / ethyl acetate / 2 h / 20 °C / 2585.81 Torr

4.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 8 h / 0 - 20 °C

5.1: potassium carbonate / acetonitrile / 16 h / 0 - 80 °C

With tributylphosphine; hydrogen; sodium hydride; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; palladium(II) hydroxide; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile;

Reference yield:

2,4-dibenzyloxybenzaldehyde (13246-46-3) → ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (1356601-56-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 16 h / 0 - 20 °C

2.1: hydrogen / palladium(II) hydroxide / ethyl acetate / 2 h / 20 °C / 2585.81 Torr

3.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 8 h / 0 - 20 °C

4.1: potassium carbonate / acetonitrile / 16 h / 0 - 80 °C

With tributylphosphine; hydrogen; sodium hydride; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; palladium(II) hydroxide; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile;

upstream raw materials:

2,4-Dihydroxybenzaldehyde

ethyl 3-{2-hydroxy-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

chloroacetonitrile

2,4-dibenzyloxybenzaldehyde

Downstream raw materials:

3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid