(2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

Base Information

Chemical Name:(2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine
CAS No.:131142-85-3
Molecular Formula:C₂₁H₂₅NO₃S
Molecular Weight:371.5
Hs Code.:

Synonyms:(2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

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Technology Process of (2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

There total 1 articles about (2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 31197-41-8,76505-19-6
crotyltributylstannane

: 212912-47-5
2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine

: 131142-85-3
(2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 - -50 ℃; for 2h;
DOI:10.1016/S0957-4166(00)86345-4

Reference yield:

: 131142-85-3
(2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

: (S)-2-[(2S,4S,5R)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: OsO₄, Me₃NO / acetone; H₂O

2: NaIO₄ / dioxane; H₂O

With sodium periodate; osmium(VIII) oxide; trimethylamine-N-oxide; In 1,4-dioxane; water; acetone;
DOI:10.1016/S0957-4166(00)86345-4

Reference yield:

: 131142-85-3
(2S,4S,5R)-4-Methyl-2-((R)-1-methyl-allyl)-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidine

: 131142-87-5
(R)-2-[(2S,4S,5R)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: OsO₄, Me₃NO / acetone; H₂O

2: NaIO₄ / dioxane; H₂O

3: NaBH₄

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; trimethylamine-N-oxide; In 1,4-dioxane; water; acetone;
DOI:10.1016/S0957-4166(00)86345-4