2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine

Base Information

• Chemical Name: 2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine
• CAS No.: 212912-47-5
• Molecular Formula: C₁₈H₂₁NO₄S
• Molecular Weight: 347.435

Synonyms:2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine

Chemical Property of 2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine

Chemical Property:

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Technology Process of 2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine

There total 2 articles about 2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-4-methylbenzene sulfonamide (108591-33-9) + trimethyl orthoformate (149-73-5) → 2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine (212912-47-5)

Guidance literature:

With pyridinium p-toluenesulfonate; In benzene; for 0.5h; Heating;

Reference yield:

N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-4-methylbenzenesulfonamide (58107-41-8,58107-43-0,108591-33-9,131142-88-6,143957-01-1,136173-99-4) + trimethyl orthoformate (149-73-5) → 2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine (212912-47-5)

Guidance literature:

pyridinium p-toluenesulfonate; In benzene; Heating;

DOI:10.1016/S0040-4039(00)94697-5

Reference yield: 95.0%

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + 2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine (212912-47-5) → 2-[(4S,5R)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-cyclohexanone (128504-49-4,128504-55-2,130930-20-0,139242-01-6,144016-23-9,144016-26-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1016/S0040-4039(00)97587-7

upstream raw materials:

N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-4-methylbenzene sulfonamide

trimethyl orthoformate

N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-4-methylbenzenesulfonamide

Downstream raw materials:

2-[(4S,5R)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-1-phenyl-propan-1-one

(R)-2-[(2R,4S,5R)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-1-phenyl-propan-1-one

2-[(4S,5R)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-cyclohexanone

2R,4S,5R,1'R-2-(2'-Oxo-2',5'-dihydroxy-5'-furyl)-4-methyl-3-p-methylphenylsulphonyl-5-phenyl-1,3-oxazolidine

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