4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate

Base Information

Chemical Name:4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate
CAS No.:1613025-51-6
Molecular Formula:C₃₀H₂₃NO₄
Molecular Weight:461.517
Hs Code.:

Synonyms:4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate

Suppliers and Price of 4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate

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Technology Process of 4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate

There total 4 articles about 4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1613025-50-5
1-(3-cyclohexylidenepenta-1,4-diyn-1-yl)-4-nitrobenzene

: 61807-37-2
benzoic acid 4‐iodophenyl ester

: 1613025-51-6
4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 4h; Inert atmosphere;
DOI:10.1002/ejoc.201301642

Reference yield:

: 1613025-49-2
3-cyclohexylidene-1-(4-nitrophenyl)-5-trimethylsilyl-1,4-pentadiyne

: 1613025-51-6
4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol; tetrahydrofuran / 7 h

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/ejoc.201301642

Reference yield:

: 244191-28-4
trifluoro-methanesulfonic acid 1-cyclohexylidene-3-trimethylsilanyl-prop-2-ynyl ester

: 1613025-51-6
4-[3-cyclohexylidene-5-(4-nitrophenyl)penta-1,4-diyn-1-yl]phenyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 15 h / Inert atmosphere

2: potassium carbonate / methanol; tetrahydrofuran / 7 h

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling;
DOI:10.1002/ejoc.201301642