(R)-Propafenone

Base Information

• Chemical Name: (R)-Propafenone
• CAS No.: 107381-31-7
• Molecular Formula: C21H27 N O3
• Molecular Weight: 341.45
• Hs Code.: 2922509090
• Mol file: 107381-31-7.mol

Synonyms:1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, (R)-; (+)-(R)-Propafenone;(+)-Propafenone; (R)-Propafenone

Chemical Property of (R)-Propafenone

Chemical Property:

• Vapor Pressure: 1.27E-11mmHg at 25°C
• Boiling Point: 519.6°Cat760mmHg
• Flash Point: 268°C
• PSA: 58.56000
• Density: 1.096g/cm³
• LogP: 3.63230
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Sparingly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

(R)-Propafenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sodium channel blocker. Antiarrhythmic (class IC).

Technology Process of (R)-Propafenone

There total 3 articles about (R)-Propafenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propafenone (107300-59-4,54063-53-5) → (R)-propafenone (107381-31-7,54063-53-5) + (S)-propafenone (107381-32-8,54063-53-5)

Guidance literature:

With chiralcel OD-H column; In methanol; Resolution of racemate;

DOI:10.1021/jm2005546

Reference yield:

propylamine (107-10-8,42939-71-9) + diethyl diazodicarboxylate (4143-61-7,218603-74-8) + 2'-hydroxy-3-phenylpropiophenone (3516-95-8) + (S)-oxiranemethanol (60456-23-7) → (R)-propafenone (107381-31-7,54063-53-5)

Guidance literature:

With hydrogenchloride; triphenylphosphine;

Reference yield:

propafenone (107300-59-4,54063-53-5) → (R)-propafenone (107381-31-7,54063-53-5)

Guidance literature:

upstream raw materials:

propafenone

propylamine

diethyl diazodicarboxylate

2'-hydroxy-3-phenylpropiophenone

Downstream raw materials:

1-{(R)-2-Hydroxy-3-[2-(3-phenyl-propionyl)-phenoxy]-propyl}-3-((R)-1-phenyl-ethyl)-1-propyl-urea

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