3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester

Base Information

Chemical Name:3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester
CAS No.:947325-42-0
Molecular Formula:C₃₁H₅₅NO₃SSi
Molecular Weight:549.934
Hs Code.:

Synonyms:3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester

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Chemical Property of 3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester

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Technology Process of 3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester

There total 3 articles about 3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 947325-41-9
2-(S)-hexadecanoylamino-3-hydroxythiopropionic acid S-phenyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 947325-42-0
3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester

Guidance literature:: With 4-methyl-morpholine; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/ol070991m

Reference yield:

: 21394-64-9,16417-38-2
N-palmitoyl-L-serine

: 947325-42-0
3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / HOBt; DCC / ethyl acetate / 16 h / 20 °C

2: 83 percent / DMAP; N-methylmorpholine / dimethylformamide / 0.5 h / 20 °C

With 4-methyl-morpholine; dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol070991m

Reference yield:

: 108-98-5
thiophenol

: 947325-42-0
3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / HOBt; DCC / ethyl acetate / 16 h / 20 °C

2: 83 percent / DMAP; N-methylmorpholine / dimethylformamide / 0.5 h / 20 °C

With 4-methyl-morpholine; dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol070991m