(R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one

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Chemical Name:(R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one
CAS No.:1428738-46-8
Molecular Formula:C₁₇H₁₆FN₇O₃S
Molecular Weight:417.424
Hs Code.:

Synonyms:(R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one

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Chemical Property of (R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one

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Technology Process of (R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one

There total 4 articles about (R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.3%

: 504438-22-6
(R)‐3‐(3‐fluoro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)‐5‐(hydroxymethyl)‐oxazolidin‐2‐one

: C₇H₇BrN₆S

: 1428738-46-8
(R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane;

Reference yield: 9.3%

: 1428738-46-8
(R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 3h;

Reference yield:

: 510729-01-8
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester

: 1428738-46-8
(R)-3-(3-fluoro-4-(5-(2-methyl-2H-tetrazol-5-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-2-yl) phenyl)-5-(hydroxylmethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -78 °C

1.2: 61 h / -78 - 20 °C

2.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 90 °C

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;