(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE

Base Information

• Chemical Name: (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE
• CAS No.: 444335-16-4
• Molecular Formula: C10H9 Br F N O3
• Molecular Weight: 290.089
• Hs Code.: 2934999090
• Mol file: 444335-16-4.mol

Synonyms:(5R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one;

Chemical Property of (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE

Chemical Property:

• Boiling Point: 401.6±35.0 °C(Predicted)
• PKA: 14.05±0.10(Predicted)
• PSA: 49.77000
• Density: 1.701±0.06 g/cm3(Predicted)
• LogP: 1.97070
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(5R)-3-(4-Bromo-3-fluorophenyl)-5-(hydroxymethyl)-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE

There total 6 articles about (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (149524-42-5) → (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one (444335-16-4,1369530-77-7)

Guidance literature:

With silver trifluoroacetate; bromine chloride; In acetonitrile; at 20 ℃; for 24h;

Reference yield: 87.0%

(4-bromo-3-fluorophenyl)carbamic acid benzyl ester (510729-01-8) + (R)-glycidyl butyrate (60456-26-0) → (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one (444335-16-4,1369530-77-7)

Guidance literature:

With lithium tert-butoxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

(S)-3-chloropropan-1,2-diol (60827-45-4) + 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate (288570-67-2) → (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one (444335-16-4,1369530-77-7)

Guidance literature:

2-methylpropyl (4-bromo-3-fluorophenyl)carbamate; With 2-methylbutan-2-ol (lithium salt); In tetrahydrofuran; at -15 ℃;

(S)-3-chloropropan-1,2-diol; With potassium tert-butylate; In tetrahydrofuran; at -25 - 10 ℃;

DOI:10.1016/j.bmcl.2003.07.021

upstream raw materials:

(S)-3-chloropropan-1,2-diol

2-methylpropyl (4-bromo-3-fluorophenyl)carbamate

(5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one

3-fluoro-4-bromophenylamine

Downstream raw materials:

3-Nitro-benzenesulfonic acid (R)-3-(4-bromo-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester

(R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one

C₁₉H₂₂BFN₂O₆

(S)‐N‐((3‐(3‐fluoro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)‐2‐oxooxazolidin‐5‐yl)methyl)acetamide