2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester

Base Information

Chemical Name:2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester
CAS No.:202390-90-7
Molecular Formula:C₂₀H₂₅IO₅
Molecular Weight:472.32
Hs Code.:

Synonyms:2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester

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Chemical Property of 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester

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Technology Process of 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester

There total 8 articles about 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 72594-60-6
1-Iodo-2-(2-iodo-ethyl)-4-methoxy-benzene

: 172270-85-8
8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane

: 1-iodo-4-methoxy-2-vinylbenzene

: 202390-90-7
2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; -78 to -20 deg C;
DOI:10.1055/s-1997-1066

Reference yield:

: 72594-56-0
2-(2-Iodo-5-methoxy-phenyl)-ethanol

: 202390-90-7
2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: NaI / acetone

3: 55 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 to -20 deg C

With sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone;
DOI:10.1055/s-1997-1066

Reference yield:

: 75534-35-9
2-(2-bromo-5-methoxyphenyl)ethan-1-ol

: 202390-90-7
2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: p-TsOH

2: n-BuLi, I₂

3: H₂SO₄ / methanol

5: NaI / acetone

6: 55 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 to -20 deg C

With n-butyllithium; sulfuric acid; iodine; toluene-4-sulfonic acid; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone;
DOI:10.1055/s-1997-1066