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2-(2-bromo-5-methoxyphenyl)ethanol is a chemical compound with a molecular formula of C9H11BrO2. This organic molecule belongs to the family of phenols, which are aromatic compounds containing a phenolic group. This particular compound is characterized by an ethanol group attached to a bromo-methoxyphenyl ring. The presence of the bromine atom can make it a useful intermediate in the synthesis of more complex organic compounds. The methoxy group typically enhances the compound's solubility in organic solvents. Like many phenols, it may have the potential for diverse reactivity depending on the specific conditions and reagents used in a reaction.

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  • 75534-35-9 Structure
  • Basic information

    1. Product Name: 2-(2-bromo-5-methoxyphenyl)ethanol
    2. Synonyms: 2-(2-bromo-5-methoxyphenyl)ethanol
    3. CAS NO:75534-35-9
    4. Molecular Formula: C9H11BrO2
    5. Molecular Weight: 231.08644
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 75534-35-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 314.8±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.444±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 14.73±0.10(Predicted)
    10. CAS DataBase Reference: 2-(2-bromo-5-methoxyphenyl)ethanol(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(2-bromo-5-methoxyphenyl)ethanol(75534-35-9)
    12. EPA Substance Registry System: 2-(2-bromo-5-methoxyphenyl)ethanol(75534-35-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 75534-35-9(Hazardous Substances Data)

75534-35-9 Usage

Uses

Used in Organic Synthesis:
2-(2-bromo-5-methoxyphenyl)ethanol is used as an intermediate in the synthesis of more complex organic compounds for various applications. The bromine atom in its structure can be a key feature for further reactions, such as cross-coupling reactions, which are widely used in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
2-(2-bromo-5-methoxyphenyl)ethanol is used as a building block in the development of new pharmaceuticals. Its unique structure, including the bromine and methoxy groups, can be exploited to create novel drug candidates with potential therapeutic properties. 2-(2-bromo-5-methoxyphenyl)ethanol's reactivity and solubility characteristics make it a valuable component in the design and synthesis of new drugs.
Used in Chemical Research:
2-(2-bromo-5-methoxyphenyl)ethanol is used as a research compound in academic and industrial laboratories. Its reactivity and structural features make it an interesting subject for studies in organic chemistry, particularly in the context of understanding reaction mechanisms, exploring new synthetic routes, and developing innovative methodologies for the preparation of complex molecules.
Used in Material Science:
2-(2-bromo-5-methoxyphenyl)ethanol is used as a component in the development of new materials with specific properties. Its chemical structure and reactivity can contribute to the creation of advanced materials for applications in areas such as electronics, coatings, and adhesives, where novel properties like improved solubility, stability, or reactivity are desired.

Check Digit Verification of cas no

The CAS Registry Mumber 75534-35-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,5,3 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 75534-35:
(7*7)+(6*5)+(5*5)+(4*3)+(3*4)+(2*3)+(1*5)=139
139 % 10 = 9
So 75534-35-9 is a valid CAS Registry Number.

75534-35-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-Bromo-5-methoxyphenyl)ethanol

1.2 Other means of identification

Product number -
Other names 2-bromo-5-methoxyphenethylalcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75534-35-9 SDS

75534-35-9Relevant articles and documents

Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase

Cui, Zhiming,Gao, Jinming,Geng, Huiling,Li, Ding,Li, Hui,Zhou, Bohang,Zhou, Le

, (2020/05/25)

As simple analogues of the natural compound chelerythrine, a novel anti-cholinesterase 2-phenylisoquinolin-2-ium scaffold was designed by structure imitation. The activity evaluation led to the discovery of seven compounds with potent anti-acetylcholinesterase activity with IC50 values of ≤0.72 μM, superior to chelerythrine and standard drugs galantamine. Particularly, compound 8y showed the excellent dual acetylcholinesterase-butyrylcholinesterase inhibition activity, superior to rivastigmine, a dual cholinesterase inhibitor drug. Furthermore, the compounds displayed a competitive anti-acetylcholinesterase mechanism with the substrate and low cytotoxicity. Molecular docking showed that the isoquinoline moiety is embedded in a cavity surrounded by four aromatic residues of acetylcholinesterase by the π-π action. Structure-activity relationship showed that the p-substituents on the C-ring can dramatically improve the anti-acetylcholinesterase activity, while 8-OMe can increase the activity against the two cholinesterases simultaneously. Thus, the title compounds emerged as promising lead compounds for the development of novel cholinesterase inhibitor agents.

INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS

-

, (2020/10/21)

The present invention relates to new inhibitors of Notch signalling pathway and its use in the treatment and/or prevention of cancers.

Enantioselective Construction of Spiro Quaternary Carbon Stereocenters via Pd-Catalyzed Intramolecular α-Arylation

Wu, Ting,Kang, Xuehua,Bai, Heng,Xiong, Wenrui,Xu, Guangqing,Tang, Wenjun,Tang, Wenjun

supporting information, p. 4602 - 4607 (2020/06/29)

We herein report the development of a sterically hindered and electron-rich P-chiral monophosphorus biaryl ligand that has enabled a general and efficient enantioselective intramolecular α-arylation, providing access to a wide series of [4.4], [4.5], and [4.6]-spirocycles with chiral benzylic quaternary carbons in high yields with good to excellent enantioselectivities. A pronounced water effect on enantioselectivity is observed.

Intramolecular Homolytic Substitution Enabled by Photoredox Catalysis: Sulfur, Phosphorus, and Silicon Heterocycle Synthesis from Aryl Halides

Garrido-Castro, Alberto F.,Salaverri, Noelia,Maestro, M. Carmen,Alemán, José

supporting information, p. 5295 - 5300 (2019/07/03)

Aryl radical generation and manipulation constitutes a long-standing challenge in organic synthesis. Photocatalytic single-electron reduction of aryl halides has been established as a premier activation pathway to reach these intermediates. The current st

ISOCHROMAN COMPOUNDS AND USES THEREOF

-

Paragraph 0204; 0206-0207, (2019/02/15)

Compounds of Formula I are described, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need are also disclosed.

Highly diastereoselective synthesis of tetralin-fused spirooxindoles via lewis acid-catalyzed C(sp3)H bond functionalization

Machida, Mizuki,Mori, Keiji

supporting information, p. 868 - 871 (2018/07/03)

A highly diastereoselective synthesis of tetralin-fused spirooxindole derivatives was described. Treatment of benzylidene oxindoles with a catalytic amount of Sc(OTf)3 in refluxing hexane afforded the target compounds in good chemical yields with excellent diastereoselectivities (up to >20:1). Detailed investigation of the reaction mechanism revealed that both interconversion of the two diastereomers and their solubility difference in reaction medium were the key to achieving excellent diastereoselectivities.

CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS

-

Paragraph 00228, (2017/09/15)

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) - mediated diseases or disorders: (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein.

Synthesis, bioactivity and structure-activity relationships of new 2-aryl-8-OR-3,4-dihydroisoquinolin-2-iums salts as potential antifungal agents

Zhu, Li-Fei,Hou, Zhe,Zhou, Kun,Tong, Zong-Bo,Kuang, Qian,Geng, Hui-Ling,Zhou, Le

, p. 2413 - 2417 (2016/07/07)

As our continuing research on antifungal dihydroisoquinolin-2-ium salts, forty 2-aryl-8-OR-3,4-dihydroisoquinolin-2-ium bromides were synthesized and characterized by spectroscopic analysis. By using the mycelium growth rate method, the compounds were evaluated for antifungal activity against three plant pathogenic fungi and structure-activity relationships (SAR) were derived. The vast majority of the compounds displayed the medium to high activity with inhibition rates of 50-100% at 150 μM. About half of the compounds were more active than their natural model compounds sanguinarine and chelerythrine for all the fungi, and part or most of them were more active than positive drugs thiabendazole and azoxystrobin. SAR analysis showed that both substitution patterns of the C-ring and the type of 8-OR group significantly influenced the activity. Thus, a series of new title compounds with excellent antifungal potency emerged.

TRICYCLIC COMPOUND AND USE THEREOF

-

Paragraph 0102; 0103; 0104, (2016/01/25)

The present invention relates to: a compound selected from the group consisting of a tricyclic compound having the structure of formula I, a pharmaceutically acceptable salt, an isomer, a solvate and a precursor thereof; and a use thereof. The compound effectively controls GPR40, and thus, can be effectively used for the prophylaxis or treatment of diseases associated with GPR40, for example, diabetes and many other diseases.

Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids

Kapadia, Nirav,Harding, Wayne

supporting information, p. 8914 - 8920 (2013/09/23)

Oxa-Pictet-Spengler cyclization and microwave-assisted C-H arylation have been implemented as key steps in the synthesis of new isochroman heterocycles containing a 4,5,6a,7-tetrahydrodibenzo[de,g]chromene motif. These isochromans may be easily transformed to phenanthrene alkaloids via acidic cleavage of the isochroman ring and standard synthetic manipulations thereafter. The route described is attractive in that it provides access to two biologically interesting scaffolds in simple and high yielding synthetic steps.

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