(1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol

Base Information

Chemical Name:(1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol
CAS No.:343969-46-0
Molecular Formula:C₃₄H₆₀O₄Si
Molecular Weight:560.933
Hs Code.:

(1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol

Synonyms:(1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol

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Chemical Property of (1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol

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Technology Process of (1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol

There total 5 articles about (1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 343969-45-9
Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

: 343969-46-0
(1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol

Guidance literature:: copper diacetate; In methanol; chloroform;
DOI:10.1016/S0040-4039(01)00317-3

Reference yield:

: 84985-78-4
(4R,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-4-((R,Z)-1-hydroxy-2-((S)-5-hydroxy-2-methylenecyclohexylidene)ethyl)-7a-methyloctahydro-1H-inden-4-ol

: 343969-46-0
(1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0.5 h / 20 °C

2: 20 percent / selenium dioxide / CH₂Cl₂; acetonitrile / 18 h / Heating

3: 88 percent / imidazole / dimethylformamide / 18 h / 20 °C

4: 96 percent / Cu(OAc)2*H₂O / methanol; CHCl₃ / 18 h / 20 °C

With 1H-imidazole; selenium(IV) oxide; copper diacetate; di-isopropyl azodicarboxylate; triphenylphosphine; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Mitsunobu reaction;

Reference yield:

: 343969-43-7
Pyridine-2-carboxylic acid (R)-3-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

: 343969-46-0
(1R,3aR,4R,7aR)-4-{(R)-2-[(3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-methylene-cyclohex-(Z)-ylidene]-1-hydroxy-ethyl}-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 20 percent / selenium dioxide / CH₂Cl₂; acetonitrile / 18 h / Heating

2: 88 percent / imidazole / dimethylformamide / 18 h / 20 °C

3: 96 percent / Cu(OAc)2*H₂O / methanol; CHCl₃ / 18 h / 20 °C

With 1H-imidazole; selenium(IV) oxide; copper diacetate; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;