Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Base Information

Chemical Name:Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester
CAS No.:343969-45-9
Molecular Formula:C₄₀H₆₃NO₅Si
Molecular Weight:666.029
Hs Code.:

Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Synonyms:Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

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Chemical Property of Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

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Technology Process of Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

There total 4 articles about Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84985-78-4
(4R,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-4-((R,Z)-1-hydroxy-2-((S)-5-hydroxy-2-methylenecyclohexylidene)ethyl)-7a-methyloctahydro-1H-inden-4-ol

: 343969-45-9
Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0.5 h / 20 °C

2: 20 percent / selenium dioxide / CH₂Cl₂; acetonitrile / 18 h / Heating

3: 88 percent / imidazole / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; selenium(IV) oxide; di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Mitsunobu reaction;

Reference yield:

: 343969-43-7
Pyridine-2-carboxylic acid (R)-3-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

: 343969-45-9
Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 20 percent / selenium dioxide / CH₂Cl₂; acetonitrile / 18 h / Heating

2: 88 percent / imidazole / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; selenium(IV) oxide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 50-14-6
Calciferol

: 343969-45-9
Pyridine-2-carboxylic acid (1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-hydroxy-2-[(1R,3aR,4R,7aR)-4-hydroxy-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / KMnO₄

2: 39 percent / Ph₃P; diisopropyl azodicarboxylate

3: 25 percent / SeO₂ / CH₂Cl₂; acetonitrile / 18 h / 45 °C

4: 88 percent / imidazole

With 1H-imidazole; potassium permanganate; selenium(IV) oxide; di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; acetonitrile; 2: Mitsunobu reaction;
DOI:10.1016/S0040-4039(01)00317-3