ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate

Base Information

Chemical Name:ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate
CAS No.:1345882-31-6
Molecular Formula:C₂₃H₂₄O₇
Molecular Weight:412.439
Hs Code.:

Synonyms:ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate

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Chemical Property of ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate

Chemical Property:

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Technology Process of ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate

There total 8 articles about ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345880-52-5
5-(3-(cyclopropylmethoxy)-2-hydroxy-4-methoxyphenyl)isobenzofuran-1(3H)-one

: 105-36-2
ethyl bromoacetate

: 1345882-31-6
ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 16h;

Reference yield:

: 64169-34-2
5-bromophthalide

: 1345882-31-6
ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 50 - 80 °C / Inert atmosphere

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

3: hydrogenchloride; water / methanol / 2 h / 20 °C

4: potassium carbonate / acetonitrile / 16 h / 80 °C

With hydrogenchloride; water; potassium acetate; potassium carbonate; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 934-00-9
3-methocycatechol

: 1345882-31-6
ethyl 2-(2-(cyclopropylmethoxy)-3-methoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / tetrachloromethane / 2 h / 20 °C

2: potassium carbonate / acetone / 2 h / 20 °C

3: potassium carbonate / acetonitrile / 1 h / 0 - 20 °C

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

5: hydrogenchloride; water / methanol / 2 h / 20 °C

6: potassium carbonate / acetonitrile / 16 h / 80 °C

With hydrogenchloride; N-Bromosuccinimide; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; tetrachloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;