2-Hydrazinyl-3-methylpyridine

Base Information

• Chemical Name: 2-Hydrazinyl-3-methylpyridine
• CAS No.: 4930-99-8
• Molecular Formula: C6H9N3
• Molecular Weight: 123.1558
• Hs Code.: 2933990090
• European Community (EC) Number: 828-195-5
• NSC Number: 70718
• DSSTox Substance ID: DTXSID30290735
• Wikidata: Q82028517
• Mol file: 4930-99-8.mol

Synonyms:2-hydrazinyl-3-methylpyridine;4930-99-8;(3-methylpyridin-2-yl)hydrazine;2-Hydrazino-3-methylpyridine;(3-METHYL-PYRIDIN-2-YL)-HYDRAZINE;MFCD07786312;NSC70718;2(1H)-Pyridinone, 3-methyl-, hydrazone;3-methyl-2-pyridylhydrazine;NCIOpen2_000326;SCHEMBL838414;(3-Methyl-2-pyridyl)hydrazine;DTXSID30290735;IRZALWDJCUHVNE-UHFFFAOYSA-N;(3-Methylpyridin-2-yl)-hydrazine;GS0003;NSC-70718;AKOS005173505;AS-5606;SB53805;BB 0262849;CS-0153434;FT-0683383;EN300-154615;F18137

Chemical Property of 2-Hydrazinyl-3-methylpyridine

Chemical Property:

• Vapor Pressure: 0.00803mmHg at 25°C
• Melting Point: 120.0-122.5 °C
• Boiling Point: 267.7°Cat760mmHg
• PKA: 9.74±0.70(Predicted)
• Flash Point: 115.7°C
• PSA: 50.94000
• Density: 1.166g/cm³
• LogP: 1.44890
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 123.079647300
• Heavy Atom Count: 9
• Complexity: 84.4

Purity/Quality:

99.3% ^*data from raw suppliers

2-Hydrazinyl-3-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(N=CC=C1)NN

Technology Process of 2-Hydrazinyl-3-methylpyridine

There total 4 articles about 2-Hydrazinyl-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-bromo-3-picoline (3430-17-9) → 3-methyl-pyridin-2-ylhydrazine (4930-99-8)

Guidance literature:

With hydrazine hydrate;

Reference yield: 49.0%

2 chloro-3-methylpyridine (18368-76-8) → 3-methyl-pyridin-2-ylhydrazine (4930-99-8)

Guidance literature:

With hydrazine hydrate; at 120 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jacs.7b02020

Reference yield:

2-fluoro-3-methylpyridine (2369-18-8) → 3-methyl-pyridin-2-ylhydrazine (4930-99-8)

Guidance literature:

With hydrazine; at 60 ℃; for 3h;

upstream raw materials:

2-bromo-3-picoline

2 chloro-3-methylpyridine

2-fluoro-3-methylpyridine

Downstream raw materials:

3-(1-(4-chlorophenyl)cyclopropyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridine

8-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS". Paragraph 1260-1262. . Retrieved 2020/01/04.
• 2、 -. "AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS". Page/Page column 72; 73. . Retrieved 2016/11/17.