2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

Base Information

Chemical Name:2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide
CAS No.:722499-79-8
Molecular Formula:C₁₈H₂₈N₂O₄
Molecular Weight:336.431
Hs Code.:

Synonyms:2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

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Technology Process of 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

There total 1 articles about 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 51-67-2
tyrosamine

: 22838-58-0
Boc-D-Val-OH

: 722499-79-8
2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/anie.200353636

Reference yield: 38.0%

: 722499-79-8
2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

: 722499-84-5
2-(R)-amino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

Guidance literature:: With methanesulfonic acid; In methanol; at 20 ℃; for 24h;
DOI:10.1002/anie.200353636

Reference yield:

: 722499-79-8
2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

: 722499-88-9
(2S,5R)-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-(4-hydroxyphenethyl)-5-isopropyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 38 percent / methanesulfonic acid / methanol / 24 h / 20 °C

2.1: dioxane / 24 h / 20 °C

2.2: 66 percent / HCl / dioxane / 48 h / 20 °C

3.1: 77 percent / pyridine / 3 h / 0 °C

With pyridine; methanesulfonic acid; In 1,4-dioxane; methanol;
DOI:10.1248/cpb.54.1662