4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-1-(trifluoroacetyl)-, (2R,5R)-

Base Information

Chemical Name:4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-1-(trifluoroacetyl)-, (2R,5R)-
CAS No.:722499-88-9
Molecular Formula:C37H37F3N2O6
Molecular Weight:662.706
Hs Code.:

4-Imidazolidinone,
3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl
]-5-(1-methylethyl)-1-(trifluoroacetyl)-, (2R,5R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-1-(trifluoroacetyl)-, (2R,5R)-

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Technology Process of 4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-1-(trifluoroacetyl)-, (2R,5R)-

There total 12 articles about 4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-1-(trifluoroacetyl)-, (2R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 407-25-0
trifluoroacetic anhydride

: 722499-86-7
(2S,5R)-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-[2-(4-hydroxyphenyl)ethyl]-5-isopropylimidazolidin-4-one

: 722499-88-9
(2S,5R)-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-(4-hydroxyphenethyl)-5-isopropyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one

Guidance literature:: With pyridine; at 0 ℃; for 3h;
DOI:10.1002/anie.200353636

Reference yield:

: 722499-79-8
2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

: 722499-88-9
(2S,5R)-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-(4-hydroxyphenethyl)-5-isopropyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 38 percent / methanesulfonic acid / methanol / 24 h / 20 °C

2.1: dioxane / 24 h / 20 °C

2.2: 66 percent / HCl / dioxane / 48 h / 20 °C

3.1: 77 percent / pyridine / 3 h / 0 °C

With pyridine; methanesulfonic acid; In 1,4-dioxane; methanol;
DOI:10.1248/cpb.54.1662

Reference yield:

: 722499-84-5
2-(R)-amino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide

: 722499-88-9
(2S,5R)-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-(4-hydroxyphenethyl)-5-isopropyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: dioxane / 24 h / 20 °C

1.2: 66 percent / HCl / dioxane / 48 h / 20 °C

2.1: 77 percent / pyridine / 3 h / 0 °C

With pyridine; In 1,4-dioxane;
DOI:10.1248/cpb.54.1662