(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide

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Chemical Name:(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide
CAS No.:247068-86-6
Molecular Formula:C₄₄H₆₈N₄O₇Si
Molecular Weight:793.132
Hs Code.:

(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide

Synonyms:(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide

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Chemical Property of (2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide

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Technology Process of (2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide

There total 9 articles about (2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 247068-85-5
(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

: 247068-80-0
(2S,3R)-2-{(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoylamino}-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid

: 247068-86-6
(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1016/S0960-894X(99)00376-5

Reference yield:

: 247068-84-4
(2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one

: 247068-80-0
(2S,3R)-2-{(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoylamino}-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid

: 247068-86-6
(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 71989-23-6,251316-98-0
Fmoc-Ile-OH

: 247068-86-6
(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 8 steps

1: 79 percent / HBTU, HOBt, i-Pr₂EtN / CH₂Cl₂ / 23 h / Ambient temperature

2: 64 percent / imidazole / tetrahydrofuran / 48 h / Ambient temperature

3: piperidine / dimethylformamide / 0.33 h / Ambient temperature

4: 99 percent / HBTU, HOBt, i-Pr₂EtN / CH₂Cl₂ / 18 h / Ambient temperature

5: 91 percent / piperidine / tetrahydrofuran / 26 h / Ambient temperature

6: 99 percent / i-Pr₂EtN / CH₂Cl₂ / 3.5 h / Ambient temperature

7: 88 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / Ambient temperature

8: 48 percent / O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, 1-hydroxy-7-azabenzotriazole, i-Pr₂EtN / CH₂Cl₂ / 18 h / Ambient temperature

With piperidine; 1H-imidazole; 1-hydroxy-7-aza-benzotriazole; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00376-5