1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI)

Base Information

Chemical Name:1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI)
CAS No.:247068-85-5
Molecular Formula:C9H17NO2.C2HF3O2
Molecular Weight:285.26000
Hs Code.:
Mol file:247068-85-5.mol

Synonyms:Carfilzomib intermediate;1-Pentanone, 2-amino-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-, (2S)-, 2,2,2-trifluoroacetate (1:1);

Suppliers and Price of 1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanoneTrifluoroacetate
50mg
$ 215.00

TRC
(2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanoneTrifluoroacetate
100mg
$ 360.00

Crysdot
(S)-2-Amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one2,2,2-trifluoroacetate 95+%
25g
$ 3270.00

Crysdot
(S)-2-Amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one2,2,2-trifluoroacetate 95+%
10g
$ 1635.00

Crysdot
(S)-2-Amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one2,2,2-trifluoroacetate 95+%
5g
$ 990.00

Crysdot
(S)-2-Amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one2,2,2-trifluoroacetate 95+%
1g
$ 260.00

Crysdot
(S)-2-Amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one2,2,2-trifluoroacetate 95+%
100mg
$ 65.00

Crysdot
(S)-2-Amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one2,2,2-trifluoroacetate 95+%
250mg
$ 104.00

ChemScene
1-Pentanone,2-amino-4-methyl-1-[(2R)-2-methyloxiranyl]-,(2S)-,trifluoroacetate9CI 99.68%
250mg
$ 165.00

ChemScene
1-Pentanone,2-amino-4-methyl-1-[(2R)-2-methyloxiranyl]-,(2S)-,trifluoroacetate9CI 99.68%
100mg
$ 99.00

Total 110 raw suppliers

Chemical Property of 1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI)

Chemical Property:

Melting Point:120 - 123° C
PSA：92.92000
LogP:2.05140
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanoneTrifluoroacetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone Trifluoroacetate is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

Technology Process of 1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI)

There total 39 articles about 1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: benzyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

: 76-05-1
trifluoroacetic acid

: 247068-85-5
(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

Guidance literature:: With palladium 10% on activated carbon; hydrogen; at 20 ℃; for 1.33333h; under 760.051 Torr; Inert atmosphere;
DOI:10.1021/ja109377p