2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole

Base Information

• Chemical Name: 2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole
• CAS No.: 855958-55-3
• Molecular Formula: C₂₄H₂₄N₂S
• Molecular Weight: 372.534
• Mol file: 855958-55-3.mol

Synonyms:2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole

Chemical Property of 2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole

There total 4 articles about 2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1H-benzimidazole (765951-63-1) + methyl iodide (74-88-4) → 2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole (855958-55-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.666667h;

DOI:10.1002/hlca.200590051

Reference yield:

(2S)-N-(2-aminophenyl)-2-benzyl-3-(benzylsulfanyl)propanamide (855958-21-3) → 2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole (855958-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / AcOH / 2.5 h / 65 °C

2: 95 percent / NaH / tetrahydrofuran / 0.67 h / 0 - 20 °C

With sodium hydride; acetic acid; In tetrahydrofuran;

DOI:10.1002/hlca.200590051

Reference yield:

(2S)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid (95798-38-2) → 2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1-methyl-1H-benzimidazole (855958-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 4-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / -20 °C

1.2: 25 percent / tetrahydrofuran / 16 h / -20 °C

2.1: 80 percent / AcOH / 2.5 h / 65 °C

3.1: 95 percent / NaH / tetrahydrofuran / 0.67 h / 0 - 20 °C

With 4-methyl-morpholine; sodium hydride; acetic acid; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1002/hlca.200590051

upstream raw materials:

2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1H-benzimidazole

methyl iodide

(2S)-N-(2-aminophenyl)-2-benzyl-3-(benzylsulfanyl)propanamide

(2S)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid