(4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester

Base Information

• Chemical Name: (4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester
• CAS No.: 51261-58-6
• Molecular Formula: C₁₃H₁₅NO₃
• Molecular Weight: 233.267

Synonyms:(4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester

Chemical Property of (4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of (4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester

There total 8 articles about (4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2S,3R)-threonine ethyl ester (23926-51-4) + ethyl benzimidate hydrochloride (5333-86-8) → (4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester (51261-58-6)

Guidance literature:

In chloroform; Heating;

DOI:10.1016/S0040-4039(00)94924-4

Reference yield: 80.0%

ethyl benzimidate hydrochloride (5333-86-8) + L-threonine ethyl ester hydrochloride → (4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester (51261-58-6)

Guidance literature:

With triethylamine;

DOI:10.1002/ejoc.201000498

Reference yield:

DL-threonine ethyl ester; hydrochloride (28528-83-8,33368-36-4,39994-70-2,62365-20-2) + benzimidic acid ethyl ester (825-60-5) → 5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester (7462-66-0,50706-27-9,50706-30-4,51261-58-6,62414-62-4,67596-98-9,122923-12-0)

Guidance literature:

With diethyl ether; water;

DOI:10.1021/ja01515a037 DOI:10.1039/jr9490000589

upstream raw materials:

(2S,3R)-threonine ethyl ester

ethyl benzimidate hydrochloride

methyl benzimidate

benzimidic acid ethyl ester

Downstream raw materials:

(4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole

(4R)-4r-methoxymethyl-5t-methyl-2-phenyl-4,5-dihydro-oxazole

ethyl (4R,5R)-5-methyl-4-(2-methoxy-4-nitrophenyl)-2-phenyl-1,3-oxazoline-4-carboxylate

ethyl (4R,5R)-5-methyl-4-(2-chloro-4-nitrophenyl)-2-phenyl-1,3-oxazoline-4-carboxylate

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