(4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole

Base Information

• Chemical Name: (4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole
• CAS No.: 104068-55-5
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 104068-55-5.mol

Synonyms:(4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole

Chemical Property of (4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole

There total 5 articles about (4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester (51261-58-6) → (4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole (104068-55-5)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/S0040-4039(00)94924-4

Reference yield:

ethyl benzimidate hydrochloride (5333-86-8) → (4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole (104068-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 85 percent / LiAlH₄ / diethyl ether / 4 h / 0 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1002/chem.200204649

Reference yield:

methyl benzimidate (7471-86-5) → (4R,5R)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole (104068-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h / Heating

2: LiAlH₄ / diethyl ether / 0.25 h / -30 °C

With lithium aluminium tetrahydride; In methanol; diethyl ether;

DOI:10.1016/S0960-894X(01)00484-X

upstream raw materials:

(4S)-5t-methyl-2-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester

ethyl benzimidate hydrochloride

methyl benzimidate

Downstream raw materials:

tosylate of (4R,5R)-4-(hydroxymethyl)-5-methyl-2-phenyl-Δ²-oxazoline

(4R)-4r-methoxymethyl-5t-methyl-2-phenyl-4,5-dihydro-oxazole