3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide

Base Information

• Chemical Name: 3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide
• CAS No.: 868287-39-2
• Molecular Formula: C₂₉H₃₈N₄O₄
• Molecular Weight: 506.645
• Mol file: 868287-39-2.mol

Synonyms:3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide

Chemical Property of 3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide

There total 3 articles about 3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[3-(methoxycarbonyl)-2-furyl]boronic acid (868286-61-7) + tert-butyl [1-(5-{3-bromo-5-[(dipropylamino)carbonyl]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate (868286-60-6) → 3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide (868287-39-2) + methyl-2-{3-[5-((1R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-5-[(dipropylamino)carbonyl]phenyl}-3-furoate (868286-74-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); water; at 120 ℃; for 18h;

Reference yield:

3-bromo-5-(5-((1R)-1-[(tert-butoxycarbonyl)amino]-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl)benzoic acid (1048686-05-0) → 3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide (868287-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 50 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 18 h / 120 °C

With 1-hydroxy-7-aza-benzotriazole; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); water;

Reference yield:

di-n-propylamine (142-84-7) → 3-[5-((R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-N,N-dipropylbenzamide (868287-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 50 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 18 h / 120 °C

With 1-hydroxy-7-aza-benzotriazole; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); water;

upstream raw materials:

[3-(methoxycarbonyl)-2-furyl]boronic acid

tert-butyl [1-(5-{3-bromo-5-[(dipropylamino)carbonyl]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate

3-bromo-5-(5-((1R)-1-[(tert-butoxycarbonyl)amino]-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl)benzoic acid

di-n-propylamine