WR-238605

Base Information

• Chemical Name: WR-238605
• CAS No.: 106635-81-8
• Molecular Formula: C₄H₆O₄*C₂₄H₂₈F₃N₃O₃
• Molecular Weight: 581.589
• Mol file: 106635-81-8.mol

Synonyms:Etaquine;Tafenoquine succinate;UNII-DL5J0B8VSS;tafenoquine maleate;

Chemical Property of WR-238605

Chemical Property:

• Melting Point: 146-149°
• Boiling Point: 565.6°Cat760mmHg
• Flash Point: 295.9°C
• PSA: 78.63000
• Density: 1.237g/cm³
• LogP: 6.68410
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble5mg/mL (clear solution)

Purity/Quality:

97% ^*data from raw suppliers

Tafenoquine succinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tafenoquine succinate is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the preven tion and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase. Tatenoquine is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.

Technology Process of WR-238605

There total 2 articles about WR-238605 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid (110-15-6) + tafenoquine (106635-80-7) → 8-[(4-Amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline succinate (106635-81-8)

Guidance literature:

In IMS; for 0.5h; Product distribution / selectivity; Heating / reflux;

Reference yield:

→ 8-[(4-Amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline succinate (106635-81-8)

Guidance literature:

upstream raw materials:

succinic acid

tafenoquine