(R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:(R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1401109-65-6
Molecular Formula:C₂₂H₂₃NO₄
Molecular Weight:365.429
Hs Code.:

Synonyms:(R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of (R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of (R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

There total 4 articles about (R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401109-62-3
C₂₄H₃₁NO₆

: 1401109-65-6
(R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid / 16 h / 20 °C / Inert atmosphere

2: iron pentacarbonyl / tetrahydrofuran / Irradiation; Heating; Inert atmosphere

3: triethylamine; methanesulfonyl chloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With formic acid; iron pentacarbonyl; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2012.08.048

Reference yield:

: 1401109-59-8
(R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate

: 1401109-65-6
(R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium triethylborohydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 24 h / 50 °C / Inert atmosphere

3.1: tetrahydrofuran / 3 h / -50 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: formic acid / 16 h / 20 °C / Inert atmosphere

5.1: iron pentacarbonyl / tetrahydrofuran / Irradiation; Heating; Inert atmosphere

6.1: triethylamine; methanesulfonyl chloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With formic acid; iron pentacarbonyl; lithium triethylborohydride; methanesulfonyl chloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.08.048

Reference yield:

: 1401109-60-1
(S)-benzyl (1-(benzyloxy)-3-hydroxypropan-2-yl)(2,2-dimethoxyethyl)carbamate

: 1401109-65-6
(R)-benzyl 6-(benzyloxymethyl)-4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 24 h / 50 °C / Inert atmosphere

2.1: tetrahydrofuran / 3 h / -50 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: formic acid / 16 h / 20 °C / Inert atmosphere

4.1: iron pentacarbonyl / tetrahydrofuran / Irradiation; Heating; Inert atmosphere

5.1: triethylamine; methanesulfonyl chloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With formic acid; iron pentacarbonyl; methanesulfonyl chloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.08.048