2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

Base Information

Chemical Name:2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine
CAS No.:125639-89-6
Molecular Formula:C₂₀H₂₃ClN₄O₅
Molecular Weight:434.879
Hs Code.:

Synonyms:2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

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Chemical Property of 2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

There total 4 articles about 2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103069-49-4
2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

: 125639-89-6
2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, reflux, 2.) THF, RT, 1 h

2: 136 mg / NaOEt / bis-(2-methoxy-ethyl) ether / 1 h / Heating

With sodium ethanolate; 1,1'-carbonyldiimidazole; In diethylene glycol dimethyl ether;
DOI:10.1021/jm00159a022

Reference yield:

: 103069-47-2
2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate

: 125639-89-6
2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / ethanol / 2 h / Heating

2: 74 percent / aq. NaOH / bis-(2-methoxy-ethyl) ether / 2 h / Ambient temperature

3: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, reflux, 2.) THF, RT, 1 h

4: 136 mg / NaOEt / bis-(2-methoxy-ethyl) ether / 1 h / Heating

With sodium hydroxide; sodium ethanolate; 1,1'-carbonyldiimidazole; In ethanol; diethylene glycol dimethyl ether;
DOI:10.1021/jm00159a022

Reference yield:

: 103069-48-3
2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-3-(2-cyanoethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

: 125639-89-6
2-<(2-azidoethoxy)methyl>-4(R)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / aq. NaOH / bis-(2-methoxy-ethyl) ether / 2 h / Ambient temperature

2: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, reflux, 2.) THF, RT, 1 h

3: 136 mg / NaOEt / bis-(2-methoxy-ethyl) ether / 1 h / Heating

With sodium hydroxide; sodium ethanolate; 1,1'-carbonyldiimidazole; In diethylene glycol dimethyl ether;
DOI:10.1021/jm00159a022