N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Base Information

Chemical Name:N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine
CAS No.:1438074-40-8
Molecular Formula:C₂₆H₂₈FN₅O₂
Molecular Weight:461.539
Hs Code.:

Synonyms:N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Suppliers and Price of N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

There total 11 articles about N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1438074-40-8
N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 83 °C

2: methanol; sodium hydroxide / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 - 40 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

5: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C

With hydrogenchloride; methanol; potassium carbonate; potassium iodide; sodium hydroxide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 848591-86-6
5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione

: 1438074-40-8
N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 °C / Reflux

2: dichloromethane / 0 - 20 °C

3: hydrogen; palladium(II) hydroxide / methanol

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

5: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; palladium(II) hydroxide; potassium carbonate; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 86732-22-1
2-benzyloctahydropyrrolo[3,4-c]pyrrole

: 1438074-40-8
N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0 - 20 °C

2: hydrogen; palladium(II) hydroxide / methanol

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

4: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C

With hydrogenchloride; hydrogen; palladium(II) hydroxide; potassium carbonate; potassium iodide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;