cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide

Base Information

• Chemical Name: cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide
• CAS No.: 316790-77-9
• Molecular Formula: C₁₃H₁₆BrNO₂
• Molecular Weight: 298.18
• Mol file: 316790-77-9.mol

Synonyms:cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide

Chemical Property of cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide

There total 1 articles about cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Cyclopentanecarboxylic acid chloride (4524-93-0) + 2-bromo-4-methoxyaniline (32338-02-6) → cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide (316790-77-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In diethyl ether; at 20 ℃; for 6h;

DOI:10.1016/S0040-4039(00)01426-X

Reference yield: 95.0%

allyl bromide (106-95-6) + cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide (316790-77-9) → cyclopentanecarboxylic acid allyl-(2-bromo-4-methoxy-phenyl)-amide (316790-82-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 8h;

DOI:10.1016/S0040-4039(00)01426-X

Reference yield:

cyclopentanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide (316790-77-9) → 2-(4-methoxy-phenyl)-4-methyl-2-aza-spiro[4.4]nonan-1-one (316790-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaH / tetrahydrofuran / 8 h

2: 71 percent / tributyltin hydride; azoisobutyronitrile / toluene / 2 h / 110 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; toluene; 1: Alkylation / 2: Cyclization;

DOI:10.1016/S0040-4039(00)01426-X

upstream raw materials:

Cyclopentanecarboxylic acid chloride

2-bromo-4-methoxyaniline

Downstream raw materials:

cyclopentanecarboxylic acid allyl-(2-bromo-4-methoxy-phenyl)-amide

2-(4-methoxy-phenyl)-4-methyl-2-aza-spiro[4.4]nonan-1-one