32338-02-6

Basic information

• Product Name: 2-BROMO-4-METHOXY-PHENYLAMINE
• Synonyms: 2-BROMO-4-METHOXY-PHENYLAMINE;2-BROMO-4-METHOXYANILINE;2-Bromo-p-anisidine;2-N,4-N-diethyl-6-ethylsulfanyl-1,3,5-triazine-2,4-diamine;ethyl-[4-(ethylamino)-6-(ethylthio)-s-triazin-2-yl]amine;N2,N4-diethyl-6-ethylsulfanyl-1,3,5-triazine-2,4-diamine;2-Bromo-4-methoxyaniline 95%;4-Amino-3-bromoanisole, 2-Bromo-p-anisidine
• CAS NO: 32338-02-6
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.04852
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 32338-02-6.mol
• Article Data: 39

Chemical Properties

• Melting Point: 64 °C
• Boiling Point: 265.1 °C at 760 mmHg
• Flash Point: 114.1 °C
• Appearance: /
• Density: 1.531 g/cm³
• Vapor Pressure: 0.00935mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.14±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-4-METHOXY-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-METHOXY-PHENYLAMINE(32338-02-6)
• EPA Substance Registry System: 2-BROMO-4-METHOXY-PHENYLAMINE(32338-02-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 32338-02-6(Hazardous Substances Data)

Usage

Uses

2-Bromo-4-methoxyaniline is a useful reagent and reactant in organometallics, and organic reactions.

InChI:InChI=1/C7H8BrNO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

Upstream product

• 67-56-1 methanol 
• 577-19-5 2-nitrophenyl bromide 
• 700-36-7 2-bromo-4-fluoronitrobenzene 
• 522613-61-2 (2-bromo-4-methoxy-phenyl)-carbamic acid tert-butyl ester 
• 96-96-8 4-methoxy-2-nitroaniline 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 5470-65-5 3-bromo-4-nitrophenol 
• 591-20-8 3-Bromophenol 
• 104-94-9 4-methoxy-aniline 
• 106-49-0 p-toluidine 
• 95970-05-1 2,6-dibromo-4-methoxyaniline 
• 98447-30-4 2-bromo-4-methoxy-1-nitrobenzene 

Downstream Products

• 116707-97-2 N-(2-bromo-4-methoxyphenyl)acrylamide 
• 159766-74-2 N,N-diallyl-2-bromo-4-methoxyaniline 
• 207511-27-1 4-(2-Bromo-4-methoxy-phenylimino)-piperidine-1-carboxylic acid tert-butyl ester 
• 264909-77-5 N-(2-bromo-4-methoxyanilinomethyl)succinimide 
• 316790-75-7 cyclopropanecarboxylic acid (2-bromo-4-methoxy-phenyl)-amide 
• 591722-48-4 3-(2-bromo-4-methoxyphenylamino)benzo[b]thiophene 
• 502162-29-0 6-(4-methoxyphenyl)amino-2,3,5-trimethylbenzo[b]thiophene 
• 591722-29-1 6-(2-bromo-4-methoxyphenyl)amino-2,3,5-trimethylbenzo[b]thiophene 
• 522613-61-2 (2-bromo-4-methoxy-phenyl)-carbamic acid tert-butyl ester 
• 95970-05-1 2,6-dibromo-4-methoxyaniline 
• 95970-06-2 2,3,6-tribromo-4-methoxyaniline 
• 1335242-69-7 C₂₂H₁₇ClN₂O 
• 1335242-98-2 C₁₅H₁₄N₂O 
• 1355042-59-9 N-(2-bromo-4-methoxyphenyl)-1H-pyrrole-2-carboxamide 

Relevant articles and documents

An easy and efficient access to 2-bromo-4-methoxyaniline

2-Bromo-4-methoxyaniline was obtained by treatment of 2,6-dibromo-4-methoxyaniline with n-butyllithium.

Selective Thiocyanation and Aromatic Amination to Achieve Organized Annulation of Enaminone with Thiocyanate

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields.

COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS

Provided herein is novel compounds of formula (I), (II), (III), (IV), and (V) as described in the specification, and pharmaceutically acceptable salts, solvates, and prodrugs and compositions thereof, and methods of measuring hedgehog pathway activation in tumor cells, examining tumor cell proliferation, differentiation and apoptosis and using the compounds and pharmaceutical compositions disclosed for treatment of diseases and disorders associated with the hedgehog signaling pathway.