(E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester

Base Information

• Chemical Name: (E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester
• CAS No.: 152976-10-8
• Molecular Formula: C₂₂H₃₂Cl₃NO₄Si
• Molecular Weight: 508.945
• Mol file: 152976-10-8.mol

Synonyms:(E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester

Chemical Property of (E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester

There total 1 articles about (E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-4-(benzylamino)-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-pentenoic acid ethyl ester (131110-81-1) + trifluoroacetyl chloride (76-02-8) → (E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester (152976-10-8)

Guidance literature:

With triethylamine; In diethyl ether;

DOI:10.1039/c39930001224

Reference yield: 82.0%

(E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester (152976-10-8) → [(S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-pyrrolidin-3-yl]-acetic acid ethyl ester

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In toluene; at 110 ℃;

DOI:10.1039/c39930001224

Reference yield: 77.0%

(E)-(S)-4-[Benzyl-(2,2,2-trichloro-acetyl)-amino]-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid ethyl ester (152976-10-8) → [(S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4,4-dichloro-5-oxo-pyrrolidin-3-yl]-acetic acid ethyl ester

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In benzene; at 80 ℃;

DOI:10.1039/c39930001224

upstream raw materials:

(S)-4-(benzylamino)-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-pentenoic acid ethyl ester

trifluoroacetyl chloride