(4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol

Base Information

Chemical Name:(4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol
CAS No.:720661-22-3
Molecular Formula:C₃₂H₃₂O₃S
Molecular Weight:496.67
Hs Code.:

Synonyms:(4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol

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Chemical Property of (4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol

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Technology Process of (4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol

There total 4 articles about (4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (4R,5R)-4-[(chloro)(diphenyl)methyl]-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolane

: 720661-22-3
(4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol

Guidance literature:: (4R,5R)-4-[(chloro)(diphenyl)methyl]-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolane; With thiourea; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

With sodium hydroxide; In diethyl ether; N,N-dimethyl-formamide; for 1h;
DOI:10.1002/hlca.201200146

Reference yield:

: 93379-48-7
(R,R)-TADDOL

: 720661-22-3
(4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; tetrachloromethane; triphenylphosphine / dichloromethane / 72 h / 20 °C

2.1: triethylamine / 1.5 h / Reflux

3.1: thionyl chloride; triethylamine / dichloromethane / 1.5 h / Reflux

4.1: thiourea / N,N-dimethyl-formamide / 72 h / 20 °C

4.2: 1 h

With pyridine; tetrachloromethane; thionyl chloride; triethylamine; thiourea; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 1.1: Appel reaction;
DOI:10.1002/hlca.201200146

Reference yield:

: 147700-67-2
(4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol

: 720661-22-3
(4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1.5 h / Reflux

2.1: thionyl chloride; triethylamine / dichloromethane / 1.5 h / Reflux

3.1: thiourea / N,N-dimethyl-formamide / 72 h / 20 °C

3.2: 1 h

With thionyl chloride; triethylamine; thiourea; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201200146