(4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol

Base Information

• Chemical Name: (4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol
• CAS No.: 147700-67-2
• Molecular Formula: C₃₁H₂₉ClO₃
• Molecular Weight: 485.022

Synonyms:(4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol

Chemical Property of (4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol

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Technology Process of (4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol

There total 2 articles about (4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(R,R)-TADDOL (93379-48-7) → (4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol (147700-67-2)

Guidance literature:

With pyridine; tetrachloromethane; triphenylphosphine; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1002/hlca.201200146

Reference yield:

(R,R)-TADDOL (93379-48-7) → (4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol (147700-67-2) + (3R,4R)-2,2,5,5-tetraphenyl-tetrahydrofuran-3,4-diol

Guidance literature:

With water; methanesulfonyl chloride; triethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 5 min, 2.) CH₂Cl₂, 3 h;

Reference yield: 83.0%

diphenylamine (122-39-4) + (4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol (147700-67-2) → (4R,5S)-5-[(4-anilinophenyl-diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolan-4-methanol

Guidance literature:

In dichloromethane; at 20 ℃; for 120h;

DOI:10.1021/ol990060d

upstream raw materials:

(R,R)-TADDOL

Downstream raw materials:

(4R,5S)-5-(azido-diphenyl-methyl)-2,2-dimethyl-α,α-diphenyl-1,3-dioxolan-4-methanol

(4R,5S)-5-(amino-diphenyl-methyl)-2,2-dimethyl-α,α-diphenyl-1,3-dioxolan-4-methanol

(4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol

(4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin

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