(S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester
CAS No.:132970-46-8
Molecular Formula:C₂₃H₃₅NO₆
Molecular Weight:421.534
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester

Suppliers and Price of (S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester

There total 6 articles about (S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 132990-93-3
(E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester

: 132970-46-8
(S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester

Guidance literature:: With hydrogen; [Rh((R,R)-DIPAMP)(COD)]BF₄; In ethanol; for 72h; under 2250.2 Torr; Ambient temperature;
DOI:10.1055/s-1991-26378

Reference yield:

: 82258-55-7
Ethyl 5-benzyloxy-2-(ethoxycarbonyl)pentanoate

: 132970-46-8
(S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / LiAlH₄ / diethyl ether / 5 h / Heating

2: 89 percent / TsOH / 12 h / Ambient temperature

3: 72 percent / H₂, AcOH / 5percent Pd/C / 3 h / 2250.2 Torr

4: 57 percent / pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 2 h / Ambient temperature

5: 1) t-BuOK / 1) -70 deg C, 15 min 2) a) -70 deg C, 0.5 h b) to 35 deg C, 4.5 h

6: 96 percent / H₂ / ⁽¹⁺⁾*BF₄^(1-) / ethanol / 72 h / 2250.2 Torr / Ambient temperature

With lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; sodium acetate; toluene-4-sulfonic acid; acetic acid; pyridinium chlorochromate; palladium on activated charcoal; [Rh((R,R)-DIPAMP)(COD)]BF₄; In diethyl ether; ethanol; dichloromethane;
DOI:10.1055/s-1991-26378

Reference yield:

: 132970-29-7
5-(3-Hydroxypropyl)-2,2-dimethyl-1,3-dioxane

: 132970-46-8
(S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 2 h / Ambient temperature

2: 1) t-BuOK / 1) -70 deg C, 15 min 2) a) -70 deg C, 0.5 h b) to 35 deg C, 4.5 h

3: 96 percent / H₂ / ⁽¹⁺⁾*BF₄^(1-) / ethanol / 72 h / 2250.2 Torr / Ambient temperature

With potassium tert-butylate; hydrogen; sodium acetate; pyridinium chlorochromate; [Rh((R,R)-DIPAMP)(COD)]BF₄; In ethanol; dichloromethane;
DOI:10.1055/s-1991-26378