(E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester

Base Information

Chemical Name:(E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester
CAS No.:132990-93-3
Molecular Formula:C₂₃H₃₃NO₆
Molecular Weight:419.518
Hs Code.:

Synonyms:(E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester

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Chemical Property of (E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester

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Technology Process of (E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester

There total 5 articles about (E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82258-55-7
Ethyl 5-benzyloxy-2-(ethoxycarbonyl)pentanoate

: 132990-93-3
(E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / LiAlH₄ / diethyl ether / 5 h / Heating

2: 89 percent / TsOH / 12 h / Ambient temperature

3: 72 percent / H₂, AcOH / 5percent Pd/C / 3 h / 2250.2 Torr

4: 57 percent / pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 2 h / Ambient temperature

5: 1) t-BuOK / 1) -70 deg C, 15 min 2) a) -70 deg C, 0.5 h b) to 35 deg C, 4.5 h

With lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; sodium acetate; toluene-4-sulfonic acid; acetic acid; pyridinium chlorochromate; palladium on activated charcoal; In diethyl ether; dichloromethane;
DOI:10.1055/s-1991-26378

Reference yield:

: 132970-27-5
2-(3-(benzyloxy)propyl)propane-1,3-diol

: 132990-93-3
(E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / TsOH / 12 h / Ambient temperature

2: 72 percent / H₂, AcOH / 5percent Pd/C / 3 h / 2250.2 Torr

3: 57 percent / pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 2 h / Ambient temperature

4: 1) t-BuOK / 1) -70 deg C, 15 min 2) a) -70 deg C, 0.5 h b) to 35 deg C, 4.5 h

With potassium tert-butylate; hydrogen; sodium acetate; toluene-4-sulfonic acid; acetic acid; pyridinium chlorochromate; palladium on activated charcoal; In dichloromethane;
DOI:10.1055/s-1991-26378

Reference yield:

: 132970-28-6
5-(3-Benzyloxypropyl)-2,2-dimethyl-1,3-dioxane

: 132990-93-3
(E)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-[1,3]dioxan-5-yl)-pent-2-enoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / H₂, AcOH / 5percent Pd/C / 3 h / 2250.2 Torr

2: 57 percent / pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 2 h / Ambient temperature

3: 1) t-BuOK / 1) -70 deg C, 15 min 2) a) -70 deg C, 0.5 h b) to 35 deg C, 4.5 h

With potassium tert-butylate; hydrogen; sodium acetate; acetic acid; pyridinium chlorochromate; palladium on activated charcoal; In dichloromethane;
DOI:10.1055/s-1991-26378